89-7815-52 ［取扱停止］Recombinant Mouse PPM1A Protein (His Tag) 50ug PKSM040761
[Elabscience]
特徴
- 背景：Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：> 98 % as determined by SDS-PAGE
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_032936.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Trp 382
- 遺伝子構造：A DNA sequence encoding the mouse PPM1A (NP_032936.1) (Met 1-Trp 382) was expressed, with a polyhistide tag at the C-terminus.
- 別名（遺伝子名）：2310003C21Rik;2900017D14Rik;AI427932;AU017636;MMPa-2;MPPa-1
- 分子量：43.3 kDa
- 組成：Lyophilized from sterile 10mM HEPES, 500 NaCl, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38815-Elabscience-PKSM040761.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7815-52
Recombinant Mouse PPM1A Protein (His Tag) 50ug
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89-7815-53
Recombinant Mouse PPM1A Protein (His Tag) 100ug
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