89-7814-69 ［取扱停止］Recombinant Mouse GLO1/Glyoxalase 1 Protein (His Tag) 20ug PKSM040716
[Elabscience]
特徴
- 背景：Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. GLO1 / Glyoxalase I has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. GLO1 / Glyoxalase I catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. GLO1 / Glyoxalase I exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties. GLO1 upregulation may play a functional role in glycolytic adaptations of cancer cells.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_079650.3
- タグ種類：N-His
- アミノ酸配列：Ala 2-Ile 184
- 遺伝子構造：A DNA sequence encoding the mouse GLO1 (NP_079650.3) (Ala 2-Ile 184) was expressed, with a polyhistide tag at the N-terminus.
- 別名（遺伝子名）：0610009E22Rik;1110008E19Rik;2510049H23Rik;AW550643;Glo-1;Glo-1r;Glo-1s;Glo1-r;Glo1-s;GLY1;Qglo
- 分子量：21.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107152-Elabscience-PKSM040716.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7814-70
Recombinant Mouse GLO1/Glyoxalase 1 Protein (His Tag) 100ug
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89-7814-69
Recombinant Mouse GLO1/Glyoxalase 1 Protein (His Tag) 20ug
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