89-7814-41 ［取扱停止］Recombinant Mouse CD39/ENTPD1 Protein (His Tag)(Active) 10ug PKSM040702
[Elabscience]
特徴
- 背景：CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. It is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis. In the nervous system, CD39 could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：P55772
- タグ種類：C-His
- アミノ酸配列：Thr 38-Ile 478
- 遺伝子構造：A DNA sequence encoding the mouse ENTPD1 (P55772) extracellular domain (Thr 38-Ile 478) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
- 活性：Measured by its ability to hydrolyze the 5’phosphategroups from the substrate adenosine 5’triphosphate(ATP).The specific activity is > 25,000 pmoles/min/μg.
- 別名（遺伝子名）：Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD39
- 分子量：51 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38779-Elabscience-PKSM040702.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7814-42
Recombinant Mouse CD39/ENTPD1 Protein (His Tag)(Active) 20ug
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89-7814-41
Recombinant Mouse CD39/ENTPD1 Protein (His Tag)(Active) 10ug
|
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