89-7813-99 ［取扱停止］Recombinant Mouse CD80/B7-1 Protein (Fc Tag)(Active) 200ug PKSM040680
[Elabscience]
特徴
- 背景：The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：200ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q00609-1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Lys 245
- 遺伝子構造：A DNA sequence encoding the mouse CD80 (Q00609-1) extracellular domain (Met 1-Lys 245) was fused with the Fc region of human IgG1 at the C-terminus.
- 活性：1. Measured by its binding ability in a functional ELISA.2. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind mouse CD80-Fc, The EC50 of mouse CD80-Fc is 28 ng/mL.
- 別名（遺伝子名）：T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80;Cd28l;Ly-53;Ly53;MIC17;TSA1
- 分子量：50.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107141-Elabscience-PKSM040680.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7813-98
Recombinant Mouse CD80/B7-1 Protein (Fc Tag)(Active) 100ug
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89-7813-99
Recombinant Mouse CD80/B7-1 Protein (Fc Tag)(Active) 200ug
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