89-7813-83 Recombinant Mouse SHP2/PTPN11 Protein (His Tag)(Active) 200ug PKSM040671
[Elabscience]
特徴
- 背景：SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
仕様
- サイズ：200ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：P35235-2
- タグ種類：C-His
- アミノ酸配列：Met1-Arg593
- 遺伝子構造：A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006).The specific activity is > 1 pmoles/min/μg.
- 別名（遺伝子名）：2700084A17Rik;AW536184;PTP1D;PTP2C;SAP-2;SH-PTP2;SH-PTP3;SHP-2;Shp2;Syp
- 分子量：69.5 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38758-Elabscience-PKSM040671.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7813-83
Recombinant Mouse SHP2/PTPN11 Protein (His Tag)(Active) 200ug
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89-7813-82
Recombinant Mouse SHP2/PTPN11 Protein (His Tag)(Active) 100ug
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