89-7813-64 ［取扱停止］Recombinant Mouse GPNMB/Osteoactivin Protein (His Tag) 50ug PKSM040661
[Elabscience]
特徴
- 背景：GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q99P91
- タグ種類：C-His
- アミノ酸配列：Met1-Asn502
- 遺伝子構造：A DNA sequence encoding the mouse GPNMB (Q99P91) (Met1-Asn502) was expressed with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：DC-HIL;Dchil;ipd
- 分子量：54.9 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38751-Elabscience-PKSM040661.pdf
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89-7813-64
Recombinant Mouse GPNMB/Osteoactivin Protein (His Tag) 50ug
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89-7813-65
Recombinant Mouse GPNMB/Osteoactivin Protein (His Tag) 100ug
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