89-7812-48 Recombinant Mouse EphB3/HEK2 Protein (His Tag)(Active) 200ug PKSM040600
[Elabscience]
特徴
- 背景：Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
仕様
- サイズ：200ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 94 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_034273.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Thr 537
- 遺伝子構造：A DNA sequence encoding the mouse EPHB3 (NP_034273.1) extracellular domain (Met 1-Thr 537) was expressed, fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA. Immobilized mouse EphB3 at 2 μg/ml (100 μl/well) can bind mouse EFNB1 with a linear range of 0.1-12.5 ng/ml.
- 別名（遺伝子名）：AW456895;Cek10;Etk2;HEK2;MDK5;Sek4;Tyro6
- 分子量：57 kDa
- 組成：Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107119-Elabscience-PKSM040600.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7812-47
Recombinant Mouse EphB3/HEK2 Protein (His Tag)(Active) 100ug
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89-7812-48
Recombinant Mouse EphB3/HEK2 Protein (His Tag)(Active) 200ug
|
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