89-7811-95 Recombinant Mouse Semaphorin 3A/SEMA3A Protein (Fc Tag) 50ug PKSM040574
[Elabscience]
特徴
- 背景：Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 500 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 80 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：O08665
- タグ種類：N-Fc
- アミノ酸配列：Lys 26-Phe 546
- 遺伝子構造：A DNA sequence encoding the N-terminal fragment (Lys 26-Phe 546) of mouse SEMA3A (O08665) was fused with the Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：coll-1;Hsema-I;SEMA1;Semad;SemD
- 分子量：87.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38685-Elabscience-PKSM040574.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7811-94
Recombinant Mouse Semaphorin 3A/SEMA3A Protein (Fc Tag) 20ug
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89-7811-95
Recombinant Mouse Semaphorin 3A/SEMA3A Protein (Fc Tag) 50ug
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