89-7811-60 ［取扱停止］Recombinant Mouse Carbonic Anhydrase IX/CA9 Protein (His Tag)(Active) 10ug PKSM040557
[Elabscience]
特徴
- 背景：Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_647466.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Asp 390
- 遺伝子構造：A DNA sequence encoding the extracellular domain of mouse CAR9 (NP_647466.2) (Met 1-Asp 390) was expressed, with a C-terminal polyhistidine tag.
- 活性：Measured by its esterase activity. The specific activity is >100 pmoles/min/μg.
- 別名（遺伝子名）：RP23-195K8.9, CAIX, Ca9, MN/CA9
- 分子量：40.3 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38672-Elabscience-PKSM040557.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7811-61
Recombinant Mouse Carbonic Anhydrase IX/CA9 Protein (His Tag)(Active) 20ug
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89-7811-60
Recombinant Mouse Carbonic Anhydrase IX/CA9 Protein (His Tag)(Active) 10ug
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