89-7810-83 ［取扱停止］Recombinant Mouse SMAD2 Protein (His & GST Tag) 20ug PKSM040517
[Elabscience]
特徴
- 背景：SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. Phosphorylated SMAD2 is able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q62432-Isoform Long
- タグ種類：N-His-GST
- アミノ酸配列：Ser2-Ser467
- 遺伝子構造：A DNA sequence encoding the mouse SMAD2 (Q62432-Isoform Long) (Ser2-Ser467) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 別名（遺伝子名）：7120426M23Rik;Madh2;Madr2;mMad2;Smad-2
- 分子量：80 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM Nacl, pH 8.0, 10% glycerol, 3mM DTT
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38643-Elabscience-PKSM040517.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7810-84
Recombinant Mouse SMAD2 Protein (His & GST Tag) 100ug
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89-7810-83
Recombinant Mouse SMAD2 Protein (His & GST Tag) 20ug
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