89-7809-99 Recombinant Mouse SIRPB1A/SIRP beta 1 Protein (His Tag) 50ug PKSM040471
[Elabscience]
特徴
- 背景：SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing a 110- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：BAD26610.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Lys 363
- 遺伝子構造：A DNA sequence encoding the mouse SIRPB1A (BAD26610.1) (Met 1-Lys 363) was expressed, with a C-terminal polyhistidine tag.
- 別名（遺伝子名）：9930027N05Rik;SIRP-beta;Sirpb;Sirpb1;Sirpb1a
- 分子量：39.1 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107088-Elabscience-PKSM040471.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7809-99
Recombinant Mouse SIRPB1A/SIRP beta 1 Protein (His Tag) 50ug
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89-7809-98
Recombinant Mouse SIRPB1A/SIRP beta 1 Protein (His Tag) 20ug
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