89-7809-58 ［取扱停止］Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active) 20ug PKSM040450
[Elabscience]
特徴
- 背景：PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：P29351-2
- タグ種類：N-His-GST
- アミノ酸配列：Ala207-Lys597
- 遺伝子構造：A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 4 μmoles/min/μg.
- 別名（遺伝子名）：70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1
- 分子量：72.7 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107079-Elabscience-PKSM040450.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7809-59
Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active) 100ug
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89-7809-58
Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active) 20ug
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