89-7808-87 ［取扱停止］Recombinant Mouse OBCAM/OPCML Protein (aa 1-541, His Tag)(Active) 50ug PKSM040415
[Elabscience]
特徴
- 背景：The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 98 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q9R069
- タグ種類：C-His
- アミノ酸配列：Met 1-Ala 541
- 遺伝子構造：A DNA sequence encoding the extracellular domain of mouse BCAM (Q9R069) (Met 1-Ala 541) was expressed, with a C-terminal polyhistidine tag.
- 活性：Measured by the ability of the immobilized protein to support the adhesion of HOS human osteogenic sarcoma cells.When cells are added to coated plates(5 μg/mL, 100μL/well), approximately 30-70% will adhere after 1 hour at 37℃.
- 別名（遺伝子名）：1200005K12Rik;B-CAM;Gplu;Lu
- 分子量：58.3 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38574-Elabscience-PKSM040415.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7808-88
Recombinant Mouse OBCAM/OPCML Protein (aa 1-541, His Tag)(Active) 100ug
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89-7808-87
Recombinant Mouse OBCAM/OPCML Protein (aa 1-541, His Tag)(Active) 50ug
|
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