89-7808-48 Recombinant Mouse ADAM15 Protein (His Tag)(Active) 100ug PKSM040394
[Elabscience]
特徴
- 背景：ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：O88839-1
- タグ種類：C-His
- アミノ酸配列：Met 1-Thr 697
- 遺伝子構造：A DNA sequence encoding the mouse ADAM15 (O88839-1) extracellular domain (Met 1-Thr 697) was expressed, with a C-terminal polyhistidine tag.
- 活性：1. Measured by its ability to bind human PTK6 in a functional ELISA.2. Measured by its ability to bind human SRC in a functional ELISA.3. Measured by its ability to bind mouse SRC in a functional ELISA. 4. Measured by its ability to bind human LYN in a functional ELISA.
- 別名（遺伝子名）：MDC15;metargidin
- 分子量：74.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38562-Elabscience-PKSM040394.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7808-47
Recombinant Mouse ADAM15 Protein (His Tag)(Active) 20ug
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89-7808-48
Recombinant Mouse ADAM15 Protein (His Tag)(Active) 100ug
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