89-7808-32 ［取扱停止］Recombinant Mouse DPP7/DPPII/DPP2 Protein (His Tag)(Active) 20ug PKSM040386
[Elabscience]
特徴
- 背景：DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 92 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q9ET221
- タグ種類：C-His
- アミノ酸配列：Met1-Arg 506
- 遺伝子構造：A DNA sequence encoding the mouse DPP7 (Q9ET221) (Met1-Arg 506) was expressed, with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate, Lys-Pro-AMC(KP-AMC).The specific activity is > 20,000 pmoles/min/μg.
- 別名（遺伝子名）：Dpp2;DPPII;QPP
- 分子量：53.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107058-Elabscience-PKSM040386.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7808-32
Recombinant Mouse DPP7/DPPII/DPP2 Protein (His Tag)(Active) 20ug
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89-7808-31
Recombinant Mouse DPP7/DPPII/DPP2 Protein (His Tag)(Active) 10ug
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