89-7808-23 ［取扱停止］Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active) 20ug PKSM040382
[Elabscience]
特徴
- 背景：BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q9JL18
- タグ種類：C-His
- アミノ酸配列：Met1-Pro462
- 遺伝子構造：A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/μg.
- 別名（遺伝子名）：1110059C24Rik;AEPLC;AI850424;ALP56;ARP1;ASP21;BAE2;CDA13;CEAP1;DRAP
- 分子量：49.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38553-Elabscience-PKSM040382.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7808-24
Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active) 50ug
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89-7808-23
Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active) 20ug
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