89-7808-12 Recombinant Mouse BTLA/CD272 Protein (Fc Tag)(Active) 100ug PKSM040375
[Elabscience]
特徴
- 背景：BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).Immune CheckpointImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q7TSA3
- タグ種類：C-Fc
- アミノ酸配列：Met1-Gly176
- 遺伝子構造：A DNA sequence encoding the mouse BTLA (Q7TSA3)(Met1-Gly176) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 活性：Immobilized mouse BTLA-Fc at 10 μg/ml (100 μl/well) can bind biotinylated mouse HVEM-Fch, The EC50 of biotinylated mouse HVEM-Fch is 15.7-36.7 ng/ml.
- 別名（遺伝子名）：A630002H24
- 分子量：437 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38549-Elabscience-PKSM040375.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7808-12
Recombinant Mouse BTLA/CD272 Protein (Fc Tag)(Active) 100ug
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89-7808-11
Recombinant Mouse BTLA/CD272 Protein (Fc Tag)(Active) 50ug
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