89-7807-37 Recombinant Mouse IL-5RA/IL-5 Ra Protein (Baculovirus, His Tag) (Active) 50ug PKSM040336
[Elabscience]
特徴
- 背景：Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine which is particularly important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：P21183
- タグ種類：C-His
- アミノ酸配列：Met1-Val328
- 遺伝子構造：A DNA sequence encoding the mouse IL5Ra (P21183) (Met1-Val328) was expressed with a C-terminal polyhistidine tag.
- 活性：1.Measured by its binding ability in a functional ELISA. 2.Immobilized mouse IL5Ra-His at 10μg/mL (100μL/well) can bind biotinylated mouse IL5-His, the EC50 of biotinylated mouse IL5-His is 30-100ng/mL.
- 別名（遺伝子名）：Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CD125; Il5ra; Il5r
- 分子量：36.8 kDa
- 組成：Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38519-Elabscience-PKSM040336.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7807-37
Recombinant Mouse IL-5RA/IL-5 Ra Protein (Baculovirus, His Tag) (Active) 50ug
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89-7807-36
Recombinant Mouse IL-5RA/IL-5 Ra Protein (Baculovirus, His Tag) (Active) 20ug
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