89-7806-97 ［取扱停止］Recombinant Mouse MAG/Siglec-4a Protein (ECD, Fc Tag) 20ug PKSM040314
[Elabscience]
特徴
- 背景：The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_034888.1
- タグ種類：C-Fc
- アミノ酸配列：Met1-Pro516
- 遺伝子構造：A DNA sequence encoding the mouse Mag (NP_034888.1) (Met1-Pro516) was expressed with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：Myelin-Associated Glycoprotein;MAG;Siglec-4a
- 分子量：81.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107038-Elabscience-PKSM040314.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7806-98
Recombinant Mouse MAG/Siglec-4a Protein (ECD, Fc Tag) 100ug
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89-7806-97
Recombinant Mouse MAG/Siglec-4a Protein (ECD, Fc Tag) 20ug
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