89-7806-83 ［取扱停止］Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)(Active) 20ug PKSM040305
[Elabscience]
特徴
- 背景：Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_001020566.111
- タグ種類：N-His-GST
- アミノ酸配列：Met 1-Leu 535
- 遺伝子構造：A DNA sequence encoding the mouse SRC (NP_001020566.111) (Met 1-Leu 535) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：1. The specific activity was determined to be ＞80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized recombinant Mouse SRC at 2 μg/ml (100 μl/well) can bind biotinylated human PTPRA (aa 174-793) with a linear range of 0.032-0.8 μg/ml.
- 別名（遺伝子名）：AW259666;pp60c-src
- 分子量：87.7 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38500-Elabscience-PKSM040305.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7806-84
Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)(Active) 50ug
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89-7806-83
Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)(Active) 20ug
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