89-7806-76 Recombinant Mouse MERTK/MER Protein (His & GST Tag)(Active) 50ug PKSM040301
[Elabscience]
特徴
- 背景：Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 96 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q60805
- タグ種類：N-His-GST
- アミノ酸配列：Glu573-Tyr867
- 遺伝子構造：A DNA sequence encoding the mouse MERTK (Q60805) (Glu573-Tyr867) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：The specific activity was determined to be 30 nmol/min/mg using Poly(Glu,Tyr) 4:1 as substrate
- 別名（遺伝子名）：Eyk;Mer;nmf12;Nyk
- 分子量：61.7 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38498-Elabscience-PKSM040301.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7806-75
Recombinant Mouse MERTK/MER Protein (His & GST Tag)(Active) 20ug
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89-7806-76
Recombinant Mouse MERTK/MER Protein (His & GST Tag)(Active) 50ug
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