89-7805-01 ［取扱停止］Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active) 50ug PKSH033736
[Elabscience]
特徴
- 背景：Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS).
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P25774
- タグ種類：C-His
- アミノ酸配列：Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide)
- 遺伝子構造：Recombinant Human Cathepsin S is produced by our Mammalian expression system and the target geneencoding Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) is expressed with a 6His tag atthe C-terminus.
- 活性：Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063.642 pmol/min/ug.
- 別名（遺伝子名）：Cathepsin S;CTSS;CTSS;MGC3886
- 分子量：36.9&25&11.2 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229569-Elabscience-PKSH033736.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7805-01
Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active) 50ug
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89-7804-99
Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active) 10ug
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