89-7804-93 Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94) 10ug PKSH033733
[Elabscience]
特徴
- 背景：Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus; but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; CCL26 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9Y258
- アミノ酸配列：Thr24-Leu94
- 遺伝子構造：Recombinant Human CCL26 is produced by our E.coli expression system and the target gene encoding Thr24-Leu94 is expressed.
- 別名（遺伝子名）：C-C Motif Chemokine 26; CC Chemokine IMAC; Eotaxin-3; Macrophage Inflammatory Protein 4-Alpha; MIP-4-Alpha; Small-Inducible Cytokine A26; Thymic Stroma Chemokine-1; TSC-1; CCL26; SCYA26
- 分子量：8.53 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM Tris; 1mM EDTA; 20% Glycerol; pH 9.0.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229566-Elabscience-PKSH033733.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7804-94
Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94) 50ug
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89-7804-93
Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94) 10ug
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