89-7804-71 Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)(Active) 10ug PKSH033722
[Elabscience]
特徴
- 背景：The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8， human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P42081
- タグ種類：C-His
- アミノ酸配列：Ala24-Pro247(Val185Ile)
- 遺伝子構造：Recombinant Human CD86 is produced by our Mammalian expression system and the target gene encoding Ala24-Pro247(Val185Ile) is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Human CTLA-4-Fc-Avi(Cat: PKSH033803) at 2μg/ml(100 μl/well) can bind Human B7-2-His. The ED50 of Human B7-2-His is 1.98ug/ml .
- 別名（遺伝子名）：T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2;B7-2;B7.2;CD28LG2;LAB72
- 分子量：26.69 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229555-Elabscience-PKSH033722.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7804-72
Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)(Active) 50ug
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89-7804-71
Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)(Active) 10ug
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