89-7804-42 Recombinant Human Langerin/CD207 Protein (His Tag) 50ug PKSH033707
[Elabscience]
特徴
- 背景：Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9UJ71
- タグ種類：N-His
- アミノ酸配列：Tyr64-Pro328(Val278Ala)
- 遺伝子構造：Recombinant Human Langerin is produced by our Mammalian expression system and the target gene encoding Tyr64-Pro328(Val278Ala) is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K; C-type lectin domainfamily 4, member K
- 分子量：31.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229540-Elabscience-PKSH033707.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7804-42
Recombinant Human Langerin/CD207 Protein (His Tag) 50ug
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89-7804-41
Recombinant Human Langerin/CD207 Protein (His Tag) 10ug
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