特徴
- 背景：CD217; also known as Interleukin-17 receptor A; is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F; it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1; CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK; and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q01973
- タグ種類：C-Fc
- アミノ酸配列：Gln30-Glu403
- 遺伝子構造：Recombinant Human ROR1 is produced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase; receptor-related 1; ROR1; NTRKR1
- 分子量：68.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229481-Elabscience-PKSH033648.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7803-23
Recombinant Human ROR1 Protein (Fc Tag) 50ug
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89-7803-22
Recombinant Human ROR1 Protein (Fc Tag) 10ug
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