特徴
- 背景：Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain; but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly; IL-36α inhibits PPARγ expression; which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α; along with IL-1F8 and IL-1F9; has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation; recruits a second receptor as a signaling component; forming an active heterodimeric receptor complex.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9UHA7
- アミノ酸配列：Met1-Phe158
- 遺伝子構造：Recombinant Human IL36A is produced by our E.coli expression system and the target gene encoding Met1-Phe158 is expressed.
- 別名（遺伝子名）：Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6
- 分子量：17.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS;PH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229448-Elabscience-PKSH033615.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7802-55
Recombinant Human IL1F6/IL36A Protein 10ug
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89-7802-56
Recombinant Human IL1F6/IL36A Protein 50ug
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