特徴
- 背景：Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9Y624
- タグ種類：C-His
- アミノ酸配列：Ser28-Val238
- 遺伝子構造：Recombinant Human JAM-A is produced by our Mammalian expression system and the target gene encoding Ser28-Val238 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM;JAMA;JCAM;KAT
- 分子量：23.89 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 100mM Glycine, pH 7.5.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229440-Elabscience-PKSH033607.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7802-42
Recombinant Human JAM-A/F11R Protein (His Tag) 50ug
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89-7802-41
Recombinant Human JAM-A/F11R Protein (His Tag) 10ug
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