89-7802-36 Recombinant Human LILRB4/CD85k/ILT3 Protein (aa 22-259, Fc Tag) 50ug PKSH033604
[Elabscience]
特徴
- 背景：Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4 (LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid (aa) extracellular domain with two Ig-like domains; a 22 aa transmembrane segment; and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM). Within the ECD; mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4; respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 is expressed on dendritic cells (DC); monocytes; macrophages; and vascular endothelial cells (EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling; leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells (Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn; CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes; DC; and EC.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q8NHJ6
- タグ種類：C-Fc
- アミノ酸配列：Gln22-Glu259
- 遺伝子構造：Recombinant Human LILRB4 is produced by our Mammalian expression system and the target gene encoding Gln22-Glu259 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Leukocyte immunoglobulin-like receptor subfamily B member 4; Mast cell surface Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.glycoprotein Gp49B; CD85k; Lilrb4; Gp49b
- 分子量：53.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229437-Elabscience-PKSH033604.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7802-35
Recombinant Human LILRB4/CD85k/ILT3 Protein (aa 22-259, Fc Tag) 10ug
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89-7802-36
Recombinant Human LILRB4/CD85k/ILT3 Protein (aa 22-259, Fc Tag) 50ug
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