特徴
- 背景：Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P18627
- タグ種類：C-mFc
- アミノ酸配列：Leu23-Leu450
- 遺伝子構造：Recombinant Human LAG3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a mFc tag at the C-terminus.
- 別名（遺伝子名）：Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223;LAG-3
- 分子量：72.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229428-Elabscience-PKSH033595.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7802-18
Recombinant Human LAG3/CD223 Protein (mFc Tag) 50ug
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89-7802-17
Recombinant Human LAG3/CD223 Protein (mFc Tag) 10ug
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