89-7801-92 Recombinant Human CD10/Neprilysin Protein (His Tag) 10ug PKSH033583
[Elabscience]
特徴
- 背景：Neprilysin/CD10(NEP) is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The functions is both as an endopeptidase with a thermolysin-like specificity and as a dipeptidyl-carboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA), and is expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid β peptide (Aβ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting Aβ accumulation.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P08473
- タグ種類：N-His
- アミノ酸配列：Tyr52-Trp750
- 遺伝子構造：Recombinant Human Neprilysin is produced by our Mammalian expression system and the target gene encoding Tyr52-Trp750 is expressed with a 8His tag at the N-terminus.
- 別名（遺伝子名）：Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10; MME; EPN;CALLA
- 分子量：80.9 kDa
- 組成：Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229416-Elabscience-PKSH033583.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7801-93
Recombinant Human CD10/Neprilysin Protein (His Tag) 50ug
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89-7801-92
Recombinant Human CD10/Neprilysin Protein (His Tag) 10ug
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