89-7801-83 ［取扱停止］Recombinant Human MMP8/CLG1 Protein (His Tag) 50ug PKSH033578
[Elabscience]
特徴
- 背景：Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-α and GM-CSF. MMP8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, β-casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain. MMP8 is heavily glycosylated.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P22894
- タグ種類：C-His
- アミノ酸配列：Phe21-Gly467
- 遺伝子構造：Recombinant Human MMP-8 is produced by our Mammalian expression systemand the target gene encoding Phe21-Gly467 is expressed with a 10His tag at the C-terminus.
- 別名（遺伝子名）：Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL;MMP8; CLG1
- 分子量：52.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229411-Elabscience-PKSH033578.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7801-83
Recombinant Human MMP8/CLG1 Protein (His Tag) 50ug
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89-7801-82
Recombinant Human MMP8/CLG1 Protein (His Tag) 10ug
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