89-7801-35 Recombinant Human PD-1/PDCD1 Protein (Fc Tag)(Active) 50ug PKSH033554
[Elabscience]
特徴
- 背景：Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q15116
- タグ種類：C-Fc
- アミノ酸配列：Pro21-Gln167
- 遺伝子構造：Recombinant Human PD-1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a Fc tag at the C-terminus.
- 活性：Immobilized Human PD-1-Fc at 1μg/ml(100 μl/well) can bind Biotinylated Human PD-L1-Fc(Cat: PKSH033557). The ED50 of PD-1-Fc is 38.696ug/ml .
- 別名（遺伝子名）：Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279;SLEB2;Hsle1
- 分子量：43.6 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229387-Elabscience-PKSH033554.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7801-34
Recombinant Human PD-1/PDCD1 Protein (Fc Tag)(Active) 10ug
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89-7801-35
Recombinant Human PD-1/PDCD1 Protein (Fc Tag)(Active) 50ug
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