特徴
- 背景：S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-handmotifs. S100 proteins are cell-and tissue-specific and are involved in many intra-and extracellular processes hrough interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and insolution; resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppress or protein p53; also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsivegenes; respectively. S100A16 protein is a novel adipogenesis-promoting factor.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q96FQ6
- アミノ酸配列：Met1-Ser103
- 遺伝子構造：Recombinant Human S100A16 is produced by our E.coli expression system and the target gene encoding Met1-Ser103 is expressed.
- 別名（遺伝子名）：SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI; Ly108; NTBA; SF2000
- 分子量：11.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM Tris; 500mM NaCl; pH8.0.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229382-Elabscience-PKSH033549.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7801-25
Recombinant Human S100A16/S100F Protein 50ug
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89-7801-24
Recombinant Human S100A16/S100F Protein 10ug
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