特徴
- 背景：CD4 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. Mature human CD4 consists of a 371 amino acid extracellular region containing four immunoglobulin-like domains; a 22 aa transmembrane segment; and a 40 aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. CD4 binds directly to MHC class II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and; in human; as a co-receptor for the gp120 surface glycoprotein of HIV-1.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P01730
- タグ種類：C-His
- アミノ酸配列：Lys26-Trp390
- 遺伝子構造：Recombinant Human CD4 is produced by our Mammalian expression system and the target gene encoding Lys26-Trp390 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD4;Scd4;CD4mut
- 分子量：41.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229339-Elabscience-PKSH033506.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7800-42
Recombinant Human CD4/LEU3 Protein (His Tag) 50ug
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89-7800-41
Recombinant Human CD4/LEU3 Protein (His Tag) 10ug
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