89-7800-21 Recombinant Human Transferrin Receptor/TFRC Protein (His Tag) 10ug PKSH033496
[Elabscience]
特徴
- 背景：Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. It positively regulates T and B cell proliferation through iron uptake.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 90% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P02786
- タグ種類：N-His
- アミノ酸配列：Leu101-Phe760
- 遺伝子構造：Recombinant Human TFRC is produced by our Mammalian expression system and the target gene encoding Leu101-Phe760 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Transferrin receptor protein 1; TR; TfR; Trfr; T9; p90;CD71;T9;TFR;TFR;TRFR
- 分子量：74.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,5% Trehalose,pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229329-Elabscience-PKSH033496.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7800-22
Recombinant Human Transferrin Receptor/TFRC Protein (His Tag) 50ug
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89-7800-21
Recombinant Human Transferrin Receptor/TFRC Protein (His Tag) 10ug
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