特徴
- 背景：Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains; two Ig-like C2-type domains; and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes; but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes; such as cell survival; migration; differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells; platelet aggregation; and cytoskeleton reorganization. Not only these; it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1; which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition; MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE); deficiency in MERTK are the cause of retinitis pigmentosa.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q12866
- タグ種類：C-His
- アミノ酸配列：Met177-Ala499
- 遺伝子構造：Recombinant Human MERTK is produced by our Mammalian expression system and the target gene encoding Met177-Ala499 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER; Mer
- 分子量：36 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM Tris;150mM NaCl;pH8.0.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229314-Elabscience-PKSH033481.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7799-90
Recombinant Human MERTK/MER Protein (His Tag) 10ug
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89-7799-91
Recombinant Human MERTK/MER Protein (His Tag) 50ug
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