89-7799-69 ［取扱停止］Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag) 50ug PKSH033470
[Elabscience]
特徴
- 背景：Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P56856-2
- タグ種類：N-His
- アミノ酸配列：Asp28-Leu76
- 遺伝子構造：Recombinant HumanCLDN18.2 is produced by our E.coli expression system and the target gene encoding Asp28-Leu76 is expressed with a 8His tag at the N-terminus.
- 別名（遺伝子名）：Claudin-18; CLDN18
- 分子量：19.7 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 25mM NaCl, 0.1% Triton X-100, 10% glycerol, pH 8.0.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229303-Elabscience-PKSH033470.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7799-69
Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag) 50ug
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89-7799-68
Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag) 10ug
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