89-7799-65 Recombinant Human/Mouse/Rat Irisin/FNDC5 Protein (His Tag) 50ug PKSH033461
[Elabscience]
特徴
- 背景：Fibronectin type III domain-containing protein 5; the precursor of irisin; is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD); a 21 aa transmembrane domain; and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human; mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1); mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.
仕様
- サイズ：50ug
- 種由来：Human/Mouse/Rat
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q8NAU1
- タグ種類：C-His
- アミノ酸配列：Asp32-Glu143
- 遺伝子構造：Recombinant Human/Mouse/Rat FNDC5 is produced by our Mammalian expression system and the target gene encoding Asp32-Glu143 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5
- 分子量：13.6 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229302-Elabscience-PKSH033461.pdf
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89-7799-65
Recombinant Human/Mouse/Rat Irisin/FNDC5 Protein (His Tag) 50ug
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89-7799-64
Recombinant Human/Mouse/Rat Irisin/FNDC5 Protein (His Tag) 10ug
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