89-7798-64 Recombinant Human NKG2D/CD314 Protein (His Tag)(Active) 50ug PKSH033409
[Elabscience]
特徴
- 背景：NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells; CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor; it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells; leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx; culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA; MICB; RAET1E; RAET1G; ULBP1; ULBP2; ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P26718
- タグ種類：N-6His
- アミノ酸配列：Phe78-Val216
- 遺伝子構造：Recombinant Human NKG2-D type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe78-Val216 is expressed with a 6His tag at the N-terminus.
- 活性：Immobilized Human NKG2D-His at 10μg/ml(100 μl/well) can bind Human MICA-Fc(Cat: PKSH032753). The ED50 of Human NKG2D-His is 19.8 ug/ml .
- 別名（遺伝子名）：CD314; KLRK1;CD314 antigen;Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK recepto
- 分子量：16.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS; pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-139447-Elabscience-PKSH033409.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7798-64
Recombinant Human NKG2D/CD314 Protein (His Tag)(Active) 50ug
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89-7798-63
Recombinant Human NKG2D/CD314 Protein (His Tag)(Active) 10ug
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