89-7798-40 ［取扱停止］Recombinant Human TNFR1/TNFRSF1A Protein (E.coli, His Tag)(Active) 50ug PKSH033397
[Elabscience]
特徴
- 背景：Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001056.1
- タグ種類：N-6His
- アミノ酸配列：Ile22-Thr 211
- 遺伝子構造：Recombinant Human Tumor Necrosis Factor Receptor I is produced by our E.coli expression system and the target gene encoding Ile22-Thr211 is expressed with a 6His tag at the N-terminus.
- 活性：Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. he ED50 for this effect, in the presence of 0.25 ng/mL of recombinant human TNF-alpha, is 5.47 ng/ml.
- 別名（遺伝子名）：Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor 1;TNF-R1;Tumor necrosis factor receptor type I;TNF-RI;TNFR-I;TNFAR; TNFR1
- 分子量：23.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-139435-Elabscience-PKSH033397.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7798-39
Recombinant Human TNFR1/TNFRSF1A Protein (E.coli, His Tag)(Active) 10ug
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89-7798-40
Recombinant Human TNFR1/TNFRSF1A Protein (E.coli, His Tag)(Active) 50ug
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