89-7797-13 Recombinant Human MICA Protein (His Tag)(Active) 50ug PKSH033333
[Elabscience]
特徴
- 背景：MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA shares 85% amino acid identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：AAH16929.1
- タグ種類：C-6His
- アミノ酸配列：Glu24-Gln308
- 遺伝子構造：Recombinant Human MHC Class I Polypeptide-Related Sequence A is produced by our Mammalian expression system and the target gene encoding Glu24-Gln308 is expressed with a 6His tag at the C-terminus.
- 活性：Immobilized Human NKG2DL-Fc(Cat: PKSH032815) at 10μg/ml(100 μl/well) can bind Human MICA-His.
- 別名（遺伝子名）：MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1
- 分子量：33.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-139371-Elabscience-PKSH033333.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7797-12
Recombinant Human MICA Protein (His Tag)(Active) 10ug
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89-7797-13
Recombinant Human MICA Protein (His Tag)(Active) 50ug
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