89-7795-86 Recombinant Human b-NGF/NGFB Protein (aa 122-23, Human Cells)(Active) 10ug PKSH033270
[Elabscience]
特徴
- 背景：Human b-Nerve Growth Factor (b-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α; b; and gamma; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF; NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. b-NGF is a neurotrophic factor that signals through its receptor b-NGF; and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. b-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that b-NGF is a pleiotropic cytokine; which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human b-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P01138
- アミノ酸配列：Ser122-Arg239
- 遺伝子構造：Recombinant Human beta-Nerve Growth Factor is produced by our Mammalian expression system and the target gene encoding Ser122-Arg239 is expressed.
- 活性：Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.04-0.4 ng/ml.
- 別名（遺伝子名）：Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
- 分子量：13.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB; 250mM NaCl; pH 7.0.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106931-Elabscience-PKSH033270.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7795-87
Recombinant Human b-NGF/NGFB Protein (aa 122-23, Human Cells)(Active) 50ug
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89-7795-86
Recombinant Human b-NGF/NGFB Protein (aa 122-23, Human Cells)(Active) 10ug
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