89-7795-67 Recombinant Human Beta-2-Microglobulin/B2M Protein (E.coli, His Tag) 50ug PKSH033260
[Elabscience]
特徴
- 背景：β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules; involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases; various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin; probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P61769
- タグ種類：N-6His
- アミノ酸配列：Ile21-Met 119
- 遺伝子構造：Recombinant Human beta-2-Microglobulin is produced by our E.coli expression system and the target gene encoding Ile21-Met119 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Beta-2-Microglobulin; B2M; β2-Microglobulin
- 分子量：14.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB;150mM NaCl;pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106921-Elabscience-PKSH033260.pdf
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89-7795-66
Recombinant Human Beta-2-Microglobulin/B2M Protein (E.coli, His Tag) 10ug
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89-7795-67
Recombinant Human Beta-2-Microglobulin/B2M Protein (E.coli, His Tag) 50ug
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