特徴
- 背景：Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q14CC5
- タグ種類：N-6His
- アミノ酸配列：Met 1-Ile496
- 遺伝子構造：Recombinant Human Tryptophan 5-Hydroxylase 2 is produced by our E.coli expression system and the target gene encoding Met1-Ile496 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：Tryptophan 5-Hydroxylase 2; Neuronal Tryptophan Hydroxylase; Tryptophan 5-Monooxygenase 2; TPH2; NTPH
- 分子量：58.8 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106827-Elabscience-PKSH033155.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7793-79
Recombinant Human TPH2 Protein (His Tag) 50ug
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89-7793-78
Recombinant Human TPH2 Protein (His Tag) 10ug
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