89-7793-52 Recombinant Human Transthyretin/TTR Protein (His Tag) 10ug PKSH033141
[Elabscience]
特徴
- 背景：Transthyretin is a secreted and cytoplasm protein which belongs to the Transthyretin family. Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Defects in Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P02766
- タグ種類：C-6His
- アミノ酸配列：Gly21-Glu147
- 遺伝子構造：Recombinant Human Transthyretin is produced by our Mammalian expression system and the target gene encoding Gly21-Glu147 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB;CTS;CTS1;HEL111
- 分子量：14.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106814-Elabscience-PKSH033141.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7793-52
Recombinant Human Transthyretin/TTR Protein (His Tag) 10ug
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89-7793-53
Recombinant Human Transthyretin/TTR Protein (His Tag) 50ug
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