特徴
- 背景：Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P52888
- タグ種類：C-6His
- アミノ酸配列：Lys2-Cys689
- 遺伝子構造：Recombinant Human Thimet Oligopeptidase is produced by our E.coli expression system and the target gene encoding Lys2-Cys689 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Thimet Oligopeptidase; Endopeptidase 24.15; MP78; THOP1
- 分子量：80.0 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 10% Glycerol, pH 7.0.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106780-Elabscience-PKSH033105.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7792-83
Recombinant Human THOP1 Protein (His Tag) 10ug
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89-7792-84
Recombinant Human THOP1 Protein (His Tag) 50ug
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