89-7789-91 ［取扱停止］Recombinant Human Pro-Neuregulin-1/NRG1-‑b1 Protein (aa 1-246, His Tag)(Active) 50ug PKSH032940
[Elabscience]
特徴
- 背景：neuregulin-1 (heregulin-1;NRG1) is a member of neuregulin family; which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I; type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors; concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q02297-6
- タグ種類：N-6His
- アミノ酸配列：Met 1-Lys246
- 遺伝子構造：Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Met1-Lys246 is expressed with a 6His tag at the N-terminus.
- 活性：Immobilized Human NRG1Beta-His at 10μg/ml(100 μl/well) can bind Human HER3-Fc(Cat: PKSH033438). The ED50 of Human Glypican-3-His is 5.18 ug/ml.
- 別名（遺伝子名）：Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;
- 分子量：29.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106634-Elabscience-PKSH032940.pdf
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