89-7789-22 ［取扱停止］Recombinant Human CD31/PECAM1 Protein (His Tag) 10ug PKSH032902
[Elabscience]
特徴
- 背景：Platelet Endothelial Cell Adhesion Molecule (PECAM1, CD31),is a heavily glycosylated transmembrane protein belonging to theimmunoglobulin (Ig) superfamily of cell adhesion molecules. CD31 is composed of an extracellular domain (ECD) of 574 amino acids (aa) containing six Ig-likedomains, a transmembrane domain, and a 118 aacytoplasmic domain. CD31 is highly expressed on endothelial cells and at a lower level on platelets, granulocytes,macrophages, dendritic cells, T and B cells, and natural killer (NK) cells. It is involved in cell adhesion and is required for transepithelial migration of leukocytes (TEM). CD31 acts as a homophilic receptor through itsextracellular domain and is involved in downstream signaling via its cytoplasmic domain. This domain contains highly conserved ITIM motifs which, once tyrosinephosphorylated, recruit and activate the signaling molecules Src and SHP2. The resulting inhibition of TCR signaling increases the activation threshold ofT cells, thus reinforcing peripheral tolerance and preventing development of autoimmunity. CD31 additionally regulates immune responses by acting as a keyinhibitory receptor in dendritic cell development. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P16284
- タグ種類：C-6His
- アミノ酸配列：Gln28-Lys601
- 遺伝子構造：Recombinant Human Platelet Endothelial Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Gln28-Lys601 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1
- 分子量：65.3 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106600-Elabscience-PKSH032902.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7789-22
Recombinant Human CD31/PECAM1 Protein (His Tag) 10ug
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89-7789-23
Recombinant Human CD31/PECAM1 Protein (His Tag) 50ug
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