特徴
- 背景：Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation, negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. It also involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：Human Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P48426
- タグ種類：C-6His
- アミノ酸配列：Met 1-Thr406
- 遺伝子構造：Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha is produced by our Mammalian expression system and the target gene encoding Met1-Thr406 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha;Diphosphoinositide kinase 2-alpha;PIP5KIII;Phosphatidylinositol 5-phosphate 4-kinase type II alpha;PtdIns(4)P-5-kinase B isoform;PtdIns(4)P-5-kinase C isoform;PtdIns(5)P-4-kinase isoform 2-alpha
- 分子量：47.3 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106586-Elabscience-PKSH032888.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7788-93
Recombinant Human PIP4K2A Protein (His Tag) 10ug
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89-7788-94
Recombinant Human PIP4K2A Protein (His Tag) 50ug
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